Cryptozoic Entertainment is making Mystic Warlords of Ka’a, the card game in The Big Bang Theory, into a real game.  "It’s the game that Sheldon and Wil Wheaton play against each other, and now Brent Spiner is his new nemesis," Cryptozoic COO Scott Gaeta explained.  "We’re designing the game from scratch and we’re going to put it out in the market so people can play the same game they play in the show."
Cryptozoic’s The Big Bang Theory Party Game, released earlier this year (see "'The Big Bang Theory Party Game'"), has been a major success for the company.